Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes
Identifieur interne : 003D25 ( Main/Exploration ); précédent : 003D24; suivant : 003D26Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes
Auteurs : Catherine Andre [France] ; Annie Hampe [France] ; Philippe Lachaume [France] ; Emmanuel Martin [France] ; Xao-Ping Wang [France] ; Vladimir Manus [France] ; Wei-Xin Hu [France] ; Francis Galibert [France]Source :
- Genomics [ 0888-7543 ] ; 1997.
English descriptors
- Teeft :
- Additional exons, Analogous sequences, Andre, Antisense, Antisense strand, Casein kinase, Cdna, Cdna sequences, Cell growth, Cell growth factor receptor, Chromosomal location, Chromosome, Coding, Coding exons, Common ancestor, Common ancestor gene, Computer analysis, Consensus sequence, Database, Deletion, Dense clusters, Different chromosomes, Different sizes, Dnastar package, Exon, Exon predictions, Falu, Feline retrovirus, Gene, Gene region, Gene regions, Genefinder, Genefinder programs, Genefinder software, Geno, Genomic, Genomic regions, Genomic sequence, Genomic sequences, Genomic structure, Gnma, Grail, Hexon program, Higher proportion, Human gene, Human genomic, Internal duplications, Intron, Intron expansion, Intron sequences, Kalu, Kinase, Local similarities, Mstb element, Noncoding region, Nucleic acids, Nucleotide, Nucleotide sequence, Oncogene, Opposite orientation, Paris cedex, Polyadenylation signal, Present address, Promoter, Promoter region, Promoter regions, Putative, Putative exon, Putative exons, Receptor, Region coding, Region encoding, Repetitive sequences, Respective size, Sense strand, Sequencing, Splice, Structural analysis, Structural organization, Subclass iiia, Such sequences, Tyrosine, White boxes.
Abstract
Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.
Url:
DOI: 10.1006/geno.1996.4482
Affiliations:
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type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Manus, Vladimir" sort="Manus, Vladimir" uniqKey="Manus V" first="Vladimir" last="Manus">Vladimir Manus</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Hu, Wei Xin" sort="Hu, Wei Xin" uniqKey="Hu W" first="Wei-Xin" last="Hu">Wei-Xin Hu</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Galibert, Francis" sort="Galibert, Francis" uniqKey="Galibert F" first="Francis" last="Galibert">Francis Galibert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Genomics</title><title level="j" type="abbrev">YGENO</title><idno type="ISSN">0888-7543</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="216">216</biblScope><biblScope unit="page" to="226">226</biblScope></imprint><idno type="ISSN">0888-7543</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0888-7543</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Additional exons</term><term>Analogous sequences</term><term>Andre</term><term>Antisense</term><term>Antisense strand</term><term>Casein kinase</term><term>Cdna</term><term>Cdna sequences</term><term>Cell growth</term><term>Cell growth factor receptor</term><term>Chromosomal location</term><term>Chromosome</term><term>Coding</term><term>Coding exons</term><term>Common ancestor</term><term>Common ancestor gene</term><term>Computer analysis</term><term>Consensus sequence</term><term>Database</term><term>Deletion</term><term>Dense clusters</term><term>Different chromosomes</term><term>Different sizes</term><term>Dnastar package</term><term>Exon</term><term>Exon predictions</term><term>Falu</term><term>Feline retrovirus</term><term>Gene</term><term>Gene region</term><term>Gene regions</term><term>Genefinder</term><term>Genefinder programs</term><term>Genefinder software</term><term>Geno</term><term>Genomic</term><term>Genomic regions</term><term>Genomic sequence</term><term>Genomic sequences</term><term>Genomic structure</term><term>Gnma</term><term>Grail</term><term>Hexon program</term><term>Higher proportion</term><term>Human gene</term><term>Human genomic</term><term>Internal duplications</term><term>Intron</term><term>Intron expansion</term><term>Intron sequences</term><term>Kalu</term><term>Kinase</term><term>Local similarities</term><term>Mstb element</term><term>Noncoding region</term><term>Nucleic acids</term><term>Nucleotide</term><term>Nucleotide sequence</term><term>Oncogene</term><term>Opposite orientation</term><term>Paris cedex</term><term>Polyadenylation signal</term><term>Present address</term><term>Promoter</term><term>Promoter region</term><term>Promoter regions</term><term>Putative</term><term>Putative exon</term><term>Putative exons</term><term>Receptor</term><term>Region coding</term><term>Region encoding</term><term>Repetitive sequences</term><term>Respective size</term><term>Sense strand</term><term>Sequencing</term><term>Splice</term><term>Structural analysis</term><term>Structural organization</term><term>Subclass iiia</term><term>Such sequences</term><term>Tyrosine</term><term>White boxes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Andre, Catherine" sort="Andre, Catherine" uniqKey="Andre C" first="Catherine" last="Andre">Catherine Andre</name></region><name sortKey="Galibert, Francis" sort="Galibert, Francis" uniqKey="Galibert F" first="Francis" last="Galibert">Francis Galibert</name><name sortKey="Hampe, Annie" sort="Hampe, Annie" uniqKey="Hampe A" first="Annie" last="Hampe">Annie Hampe</name><name sortKey="Hu, Wei Xin" sort="Hu, Wei Xin" uniqKey="Hu W" first="Wei-Xin" last="Hu">Wei-Xin Hu</name><name sortKey="Lachaume, Philippe" sort="Lachaume, Philippe" uniqKey="Lachaume P" first="Philippe" last="Lachaume">Philippe Lachaume</name><name sortKey="Manus, Vladimir" sort="Manus, Vladimir" uniqKey="Manus V" first="Vladimir" last="Manus">Vladimir Manus</name><name sortKey="Martin, Emmanuel" sort="Martin, Emmanuel" uniqKey="Martin E" first="Emmanuel" last="Martin">Emmanuel Martin</name><name sortKey="Wang, Xao Ping" sort="Wang, Xao Ping" uniqKey="Wang X" first="Xao-Ping" last="Wang">Xao-Ping Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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